Adjustable robust treatment-length optimization in radiation therapy

نویسندگان

چکیده

Abstract Traditionally, optimization of radiation therapy (RT) treatment plans has been done before the initiation RT course, using population-wide estimates for patients’ response to therapy. However, recent technological advancements have enabled monitoring individual patient during in form biomarkers. Although biomarker data remains subject substantial uncertainties, information extracted from this may allow plan be adapted a biologically informative way. We present mathematical framework that optimally adapts treatment-length an based on acquired mid-treatment information, while accounting inexact nature information. formulate adaptive problem as 2-stage problem, wherein about model parameters gathered first stage influences decisions second stage. Using Adjustable Robust Optimization (ARO) techniques we derive explicit optimal decision rules stage-2 and solve problem. The allows multiple worst-case solutions. To discriminate between these, introduce concept Pareto Robustly Optimal In numerical experiments lung cancer data, ARO method is benchmarked against several other static methods. case exact there sufficient space adapt, results show taking into account both robustness adaptability not necessary. inexactness particularly beneficial when (w.r.t. organ-at-risk (OAR) constraint violations) high importance. If minor OAR violations are allowed, nominal folding horizon approach (NOM-FH) good performing alternative, which can outperform ARO. Both difference performance magnitude NOM-FH highly influenced by quality.

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ژورنال

عنوان ژورنال: Optimization and Engineering

سال: 2022

ISSN: ['1389-4420', '1573-2924']

DOI: https://doi.org/10.1007/s11081-021-09709-w